Your physician will be able to determine what medications can be safely prescribed with buprenorphine. Generally psychotropic medications such as antidepressants can be combined with buprenorphine, as are most medications to treat hypertension or diabetes. However there are certain medications that have to be avoided or used with extreme caution with buprenorphine. Benzodiazepines (Xanax®, Klonopin®, Valium®) carry a particular risk of overdose when combined with buprenorphine and are generally avoided. Similarly sedative-hypnotic medications like Ambien® and prescription opioids like Perocoet® and Vicodin® are generally avoided with buprenorphine.